@article{Araújo_Morais_2020, title={Fusion of the new coronavirus (SARS-CoV-2) in human cells: the role of Angiotensin-Converting Enzyme 2 (ECA2) and Transmembrane Serine Protease 2 (TMPRSS2)}, volume={3}, url={https://iajmh.com/iajmh/article/view/110}, DOI={10.31005/iajmh.v3i0.110}, abstractNote={<p>There are several types of coronavirus, however it is known that three types are responsible for severe respiratory infection in humans: SARS-CoV (SARS), Mers-CoV (MERS) and the new SARS-CoV-2. Transmission occurs through contamination of salivary fluids, particles retained in the air by sneezing or coughing, close contact with contaminated people and surfaces. And the first symptoms occur between 2 to 14 days, called the viral incubation period. Because it is a new pathology, severe symptoms and abnormalities defy science. There are several pharmacological possibilities in testing phases. It is relevant to unveil studies on Angiotensin-Converting Enzyme 2 (ECA2) and Transmembrane Protease, serine 2 (TMPRSS2) in SARS-CoV-2, enzymatic targets with pharmacological perspectives for the treatment of COVID-19. Based on this premise, pharmaceutical products targeting the inhibition of ECA2 and TMPRSS2 have promising expectations in the treatment of SARS-CoV-2. After all, the inhibition of ACE2, an enzyme located in the main organs where the disease proliferates, has the potential to decrease the release of pro-inflammatory cytokines. While inhibition of TMPRSS2 would prevent the virus from entering human cells at the level of the upper respiratory tract.</p>}, journal={InterAmerican Journal of Medicine and Health}, author={Araújo, Igor Gomes and Morais, Arlandia Cristina Lima Nobre de}, year={2020}, month={May} }